abacavir-dolutegravir-lamivudine
Print| Trade Name(s): Triumeq | |
| Group 2: Non-Antineoplastic Hazardous | AHFS Class: HIV Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NNRTI); HIV Integrase Inhibitors |
| Formweb: abacavir-dolutegravir-lamivudine | |
| Info Links: Chemotherapy Extravasation Policy | |
| Activity | Glove | Gown | Eye | Mask (N95/PAPR) |
| Administration |  |  If powder is present from non-intact tablet or capsule | ||
| Waste/Disposal of drug | |
Handling of bodily fluids and/or contaminated materials
| Drug Form | Glove | Gown | Eye | Mask (N95/PAPR) | Shoe |
| Intact tablet or capsule from UD package | | ||||
| Non-intact, repackaged tablet or capsule | | ||||
| Oral liquid drug or feeding tube | | ||||
| Topical drug |  |  If splashing possible |  If splashing possible | If inhalation possible | |
| Powder, solution for inhalation | | | | | |
| Vial; ampule; pre-filled syringe | | If splashing possible | If inhalation possible | ||
| Intravenous solutions | | If splashing possible | If inhalation possible | ||
| Irrigation solutions | | If splashing possible | If inhalation possible |
| ICONS | DESCRIPTION |
 | Black bin |
 | Blue bin |
 | Light blue bin |
 | Green bin |
 | Purple top bin |
 | Red (sharps) bin |
 | Yellow bin |
 | Trash |
 | Controlled Substance (CsRx) bin |
 | Controlled Substance (Cactus) bin |
 | Spill kit |
| Form | Receipt Packaging | Environment | Glove | Storage | Labeling |
| All Forms | No additional action | No additional action | | May be stored within normal inventory, neutral or positive | Cautionary Labeling |
Pharmacy Non-Antineoplastic or Reproductive Risk Drugs PPE and Work Practices
| Activity | Glove | Gown | Eye | Mask (N95/PAPR) | Shoe |
| Counting | | ||||
Manipulating (Complete in HD non-sterile room) | | |  |
Pharmacy Non-Antineoplastic or Reproductive Risk Drugs PPE and Work Practices
| Form | Prep Instructions | Pneumatic Tube |
| Intact tablet/capsule from UD package | Sealed plastic bag, single pair of gloves, cautionary labeling |  |
| Non-intact, repackaged tablet or capsule | Sealed plastic bag, single pair of gloves, cautionary labeling | |
| Oral liquid drug or feeding tube | Sealed plastic bag, single pair of gloves, cautionary labeling |  |
| Topical drug | Sealed plastic bag, single pair of gloves, cautionary labeling | |
| Powder, solution for inhalation | Sealed plastic bag, single pair of gloves, cautionary labeling | |
| Vial; ampule; pre-filled syringe | Sealed plastic bag, single pair of gloves, cautionary labeling | |
| Intravenous solution | Sealed plastic bag, single pair of gloves, cautionary labeling | |
| Irrigation solution | Sealed plastic bag, single pair of gloves, cautionary labeling | |
Abacavir: Abacavir is a carbocyclic synthetic nucleoside analogue and an antiviral agent. Intracellularly, abacavir is converted by cellular enzymes to the active metabolite carbovir triphosphate, an analogue of deoxyguanosine-5'-triphosphate (dGTP). Carbovir triphosphate inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA. Viral DNA growth is terminated because the incorporated nucleotide lacks a 3'-OH group, which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation.
Reference: Drug Bank
Dolutegravir:
Dolutegravir is an HIV-1 antiviral agent. It inhibits HIV integrase by binding to the active site and blocking the strand transfer step of retroviral DNA integration in the host cell. The strand transfer step is essential in the HIV replication cycle and results in the inhibition of viral activity. Dolutegravir has a mean EC50 value of 0.5 nM (0.21 ng/mL) to 2.1 nM (0.85 ng/mL) in peripheral blood mononuclear cells (PBMCs) and MT-4 cells.
Reference: Drug Bank
Lamivudine: Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.
Reference: Drug Bank
abacavir:
- Suspected of causing genetic defects.
- Suspected of causing cancer.
- Suspected of damaging fertility or the unborn child.
- Causes serious eye irritation.
- May cause an allergic skin reaction.
Reference: SDS - Cayman Chemical
dolutegravir:
- Causes serious eye irritation.
- Causes skin irritation.
- Material may be irritating to the mucous membranes and upper respiratory tract.
- May be harmful by inhalation, ingestion, or skin absorption.
- May cause respiratory system irritation.
- To the best of our knowledge, the toxicological properties have not been thoroughly investigated.
Reference: SDS - Cayman Chemical
lamivudine:
- Suspected of damaging fertility or the unborn child.
Reference: SDS - Cayman Chemical
