nirogacestat

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Trade Name(s): Ogsiveo
Group 0: N/A AHFS Class: Antineoplastic Agents
Formweb: nirogacestat
Info Links: Chemotherapy Extravasation Policy
Mechanism of Action:

Nirogacestat is a gamma secretase inhibitor that blocks proteolytic activation of the Notch receptor. When dysregulated, Notch can activate pathways that contribute to tumor growth.

Reference: DailyMed

Exposure Risk:

  • Hazard statement(s)
  • Harmful if swallowed
  • Causes skin irritation
  • Causes serious eye irritation
  • May cause respiratory irritation

Reference: PubChem

Safety Data Sheet(s):
Source References:

DrugBank

NIH DailyMed

NIH PubChem

FDA Medication Guides

FDA Specific Drug Information

NIOSH Documents:

Approved on September 12, 2024