drospirenone-ethinyl estradiol
PrintTrade Name(s): Gianvi; Jasmiel; Loryna; Lo-Zumandimine; Nikki; Ocella; Syeda; Vestura; Yasmin; Yaz; Zarah; Zumandimine | |
Group 2: Non-Antineoplastic Hazardous | AHFS Class: Contraceptives |
Activity | Gloves | Gown | Eye/Face | Notes/Instructions |
Dispensing prepackaged formulations |
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Counting/Repackaging tablets and capsules | Recommended if pregnant, breast feeding or trying to conceive |
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Formulation | Gloves | Gown | Eye/Face | Notes/Instructions |
Tablets and capsules | (If patient requires assistance) | (If patient requires assistance) |
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Topicals, creams, vaginal rings | (If patient requires assistance) | (If patient requires assistance) |
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Type of Instance | Gloves | Gown | Mask | Eye/Face | Notes/Instructions |
Receiving undamaged HD shipping container |
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Receiving damaged HD shipping container | If container must be opened | If container must be opened | If container must be opened |
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Spill Cleanup | Large volume | Large volume |
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Reference: USP <800>
Hazardous Pharmaceutical | Trace Chemo | Biohazardous and Sharps |
1. Non-returnable hazardous, chemo and EPA regulated drugs. (Patient specific prescriptions, partially used blister packs, containers with more than 3% medication remaining) 2. Empty bottles or packaging of P-Listed drugs. (Warfarin, nicotine, epinephrine, nitroglycerin, physostigmine) 3. PPE with visible contamination from hazardous drug. | 1. Waste contaminated through contact with chemotherapeutic agents. (Empty vials, IV bags, syringes and tubing) 2. PPE worn while handling hazardous drugs with NO visible contamination. (Gowns, gloves and masks) 3. Used CSTD devices. | 1. All sharps capable of cutting or piercing the skin. (Needles/syringes, broken ampules, lancets) 2. Items contaminated with blood or other potentially infectious materials. (Tubing, bags or dressings containing blood, contaminated waste from isolation patients) |
Dosage Form | Ship to Institution or Pharmacy | Ship to Locations Outside of ODOC |
Tablets and Capsules |
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Liquid, Topical, and Transdermal |
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PPE | Standards |
Shoe Covers |
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Gowns |
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Gloves |
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Face Shields |
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Goggles |
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N95 Masks |
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Removal and Disposal |
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Reference: USP <800>
- May cause cancer [Danger Carcinogenicity]
- Suspected of causing cancer [Warning Carcinogenicity]
- May damage fertility or the unborn child [Danger Reproductive toxicity]
- May cause harm to breast-fed children [Reproductive toxicity, effects on or via lactation]
- Causes damage to organs through prolonged or repeated exposure [Danger Specific target organ toxicity, repeated exposure]
Reference: PubChem- ethinyl estradiol
Drospirenone: Progestins such as drospirenone diffuse freely into target cells in the female reproductive tract, mammary gland, hypothalamus, and the pituitary and bind to the progesterone receptor. Once bound to the receptor, progestins slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH surge.
Reference: Drug Bank
Ethinylestradiol: Estrogens diffuse into their target cells and interact with a protein receptor. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary. This cascade is initiated by initially binding to the estrogen receptors. The combination of an estrogen with a progestin suppresses the hypothalamic-pituitary system, decreasing the secretion of gonadotropin-releasing hormone (GnRH).
Reference: Drug Bank