leuprolide
PrintTrade Name(s): Camcevi; Eligard; Fensolvi; Lupron | |
Group 1: Antineoplastic Hazardous | AHFS Class: Antineoplastic Agents; Antiestrogens |
Preparation:
Injectable (IM, SubQ, IV, IR, etc.) - 1
Action | Gloves | Gown | Eye/Face | Mask | CSTD | Notes/Instructions |
Dispensing prepackaged formulations |
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Preparing an Injectable Dose | If risk of spill or splash | If risk of inhalation | If dosage form allows |
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Administration:
Injectable (IM, SubQ, IV, IR, etc.) - 1
Formulation | Gloves | Gown | Eye/Face | Mask | CSTD |
Prepared injectable (vial, syringe, IV solution*, irrigation**) | If splash possible or recommended if pregnant, breast feeding, or trying to conceive | If inhalation possible or recommended if pregnant, breast feeding, or trying to conceive | If dosage form allows | ||
Manufacturer packaged pre-filled syringe or injector | If provided in kit, or if dosage form allows |
* Intravenous tubing already attached and primed.
** Bladder, HIPEC, limb perfusion, etc.
Reference: NIOSH 2016, USP <800>
Receiving and Storage:
Storage & Handling
Type of Instance | Gloves | Gown | Mask | Eye/Face | Notes/Instructions |
Receiving undamaged HD shipping container |
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Receiving damaged HD shipping container | If container must be opened | If container must be opened | If container must be opened |
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Spill Cleanup | Large volume | Large volume |
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Reference: USP <800>
Disposal:
Disposals - All
Hazardous Pharmaceutical | Trace Chemo | Biohazardous and Sharps |
1. Non-returnable hazardous, chemo and EPA regulated drugs. (Patient specific prescriptions, partially used blister packs, containers with more than 3% medication remaining) 2. Empty bottles or packaging of P-Listed drugs. (Warfarin, nicotine, epinephrine, nitroglycerin, physostigmine) 3. PPE with visible contamination from hazardous drug. | 1. Waste contaminated through contact with chemotherapeutic agents. (Empty vials, IV bags, syringes and tubing) 2. PPE worn while handling hazardous drugs with NO visible contamination. (Gowns, gloves and masks) 3. Used CSTD devices. | 1. All sharps capable of cutting or piercing the skin. (Needles/syringes, broken ampules, lancets) 2. Items contaminated with blood or other potentially infectious materials. (Tubing, bags or dressings containing blood, contaminated waste from isolation patients) |
Transport:
Transporting
Dosage Form | Ship to Institution or Pharmacy | Ship to Locations Outside of ODOC |
Tablets and Capsules |
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Liquid, Topical, and Transdermal |
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PPE:
PPE Standards
PPE | Standards |
Shoe Covers |
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Gowns |
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Gloves |
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Face Shields |
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Goggles |
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N95 Masks |
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Removal and Disposal |
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Reference: USP <800>
Additional Information:
Assessment of Risk:
Exposure Risk:
- May damage fertility or unborn child
Reference: SDS - Cayman Chemical
Supplemental Information:
Only met the NIOSH criteria as a developmental and/or reproductive hazard
Mechanism of Action:
Leuprolide binds to the gonadotropin releasing hormone receptor and acts as a potent inhibitor of gonadotropin secretion.
Reference: Drug Bank
Safety Data Sheet(s):
Approved on January 8, 2024