ziprasidone
PrintTrade Name(s): Geodon | |
Group 3: Reproductive Hazard | AHFS Class: Atypical Antipsychotics |
Action | Gloves | Gown | Eye/Face | Mask | CSTD | |
Dispensing prepackaged formulations |
| |||||
Preparing an Injectable Dose | If risk of spill or splash | If risk of inhalation | If dosage form allows |
| ||
Activity | Gloves | Gown | Eye/Face | Mask | Notes/Instructions |
Dispensing prepackaged formulations |
| ||||
Counting/Repackaging tablets and capsules | Recommended if pregnant, breast feeding, or trying to conceive | If risk of dust inhalation |
| ||
Repackaging oral liquids | If risk of spill or splash | If risk of inhalation |
|
Formulation | Gloves | Gown | Eye/Face | Mask | CSTD |
Prepared injectable (vial, syringe, IV solution*, irrigation**) | or Recommended if pregnant, breast feeding, or trying to conceive | If splash possible or recommended if pregnant, breast feeding, or trying to conceive | If splash possible or recommended if pregnant, breast feeding, or trying to conceive | Recommended if pregnant, breast feeding, or trying to conceive | If dosage form allows |
Manufacturer packaged pre-filled syringe or injector | or Recommended if pregnant, breast feeding, or trying to conceive | if provided in kit, or if dosage form allows |
* Intravenous tubing already attached and primed.
** Bladder, HIPEC, limb perfusion, etc.
Reference: NIOSH 2016, USP <800>
Formulation | Gloves | Gown | Eye/Face | Mask | Notes/Instructions |
Tablet or capsule - from unit dose package | or Recommended if pregnant, breast feeding, or trying to conceive. |
| |||
Liquid - oral or feeding tube | or Recommended if pregnant, breast feeding, or trying to conceive. | Recommended if pregnant, breast feeding, or trying to conceive. | If potential for splash, vomit or spit up. |
|
Reference: NIOSH 2016, USP <800>
Type of Instance | Gloves | Gown | Mask | Eye/Face | Notes/Instructions |
Receiving undamaged HD shipping container |
| ||||
Receiving damaged HD shipping container | If container must be opened | If container must be opened | If container must be opened |
| |
Spill Cleanup | Large volume | Large volume |
|
Reference: USP <800>
Hazardous Pharmaceutical | Trace Chemo | Biohazardous and Sharps |
1. Non-returnable hazardous, chemo and EPA regulated drugs. (Patient specific prescriptions, partially used blister packs, containers with more than 3% medication remaining) 2. Empty bottles or packaging of P-Listed drugs. (Warfarin, nicotine, epinephrine, nitroglycerin, physostigmine) 3. PPE with visible contamination from hazardous drug. | 1. Waste contaminated through contact with chemotherapeutic agents. (Empty vials, IV bags, syringes and tubing) 2. PPE worn while handling hazardous drugs with NO visible contamination. (Gowns, gloves and masks) 3. Used CSTD devices. | 1. All sharps capable of cutting or piercing the skin. (Needles/syringes, broken ampules, lancets) 2. Items contaminated with blood or other potentially infectious materials. (Tubing, bags or dressings containing blood, contaminated waste from isolation patients) |
Dosage Form | Ship to Institution or Pharmacy | Ship to Locations Outside of ODOC |
Tablets and Capsules |
|
|
Liquid, Topical, and Transdermal |
|
|
PPE | Standards |
Shoe Covers |
|
Gowns |
|
Gloves |
|
Face Shields |
|
Goggles |
|
N95 Masks |
|
Removal and Disposal |
|
Reference: USP <800>
- May cause an allergic skin reaction.
- May cause damage to {Liver} through prolonged or repeated exposure
Reference: SDS - Cayman Chemical
Only met the NIOSH criteria as a developmental and/or reproductive hazard
The effects of ziprasidone are differentiated from other antispychotics based on it's preference and affinity for certain receptors. Ziprasidone binds to serotonin-2A (5-HT2A) and dopamine D2 receptors similar to other atypical antipsychotics; however, one key difference is that ziprasidone has a higher affinity ratio to these receptors when compared to other antipsychotics such as olanzapine, quetiapine, risperidone, and aripiprazole. Ziprasidone offers enhanced modulation of mood, notable negative symptom relief, overall cognitive improvement and reduced motor dysfunction which is linked to it's potent interaction with 5-HT2C, 5-HT1D, and 5-HT1A receptors in brain tissue. Ziprasidone can bind to norepinephrine reuptake sites with moderate affinity which may contribute to antidepressant and anxiolytic activity. Patient's taking ziprasidone will likely experience a lower incidence of orthostatic hypotension, cognitive disturbance, sedation, weight gain, and disruption in prolactin levels since ziprasidone has a lower affinity for histamine H1, muscarinic M1, and alpha1-adrenoceptors. 1
Reference: Drug Bank
Increased Mortality in Elderly Patients with Dementia Related Psychosis